Baig, M.M.F.A., Lai, W.-F. orcid.org/0000-0003-0585-6396, Akhtar, M.F. et al. (3 more authors) (2020) DNA nanotechnology as a tool to develop molecular tension probes for bio-sensing and bio-imaging applications: An up-to-date review. Nano-Structures & Nano-Objects, 23. 100523. ISSN 2352-507X
Abstract
DNA is known to be a life material that has been explored as an exciting biomaterial for bio-sensing, bio-imaging, and analytical applications. The current review focuses on describing the general concept of DNA nanotechnology including linear DNA nanotechnology, short circular DNA nanotechnology, DNA origami, and the hybrid protein–DNA nanotechnology/supramolecular approaches. We will further describe the existing strategies for the development of DNA molecular tension probes to target the cell surface receptors (mainly integrin) for bio-imaging and bio-sensing applications. The surface activation of the cellular receptors by the DNA probes will elicit the mechanical responses to the cells for the analysis and bio-imaging of mechano-biological processes. The literature overview is obvious about the role of cell surface receptors in generating piconewton (pN) forces and carrying out mechano-transduction events necessary for the growth, development, and proper functioning of the cells. The last part of the review will briefly summarize our contribution as a latest advancement in this field, and to establish a further need for research.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | DNA (Deoxyribose nucleic acids); Bio-imaging; Bio-sensing; Mechano-transduction; Piconewton (pN) forces |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Jul 2024 08:48 |
Last Modified: | 31 Jul 2024 08:48 |
Published Version: | https://www.sciencedirect.com/science/article/pii/... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.nanoso.2020.100523 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215503 |