Edafe, O., Tan, E.T., Jackson, R. et al. (3 more authors) (2023) Evaluation of hypoparathyroidism following laryngectomy. The Annals of The Royal College of Surgeons of England, 105 (1). pp. 62-67. ISSN 0035-8843
Abstract
Background
Hypoparathyroidism is a recognised complication following laryngectomy; it is associated with significant short-and long-term morbidity. This study aimed to further characterise this condition, identify risk factors and describe preventative and management strategies in a large cohort.
Materials and methods
This was a retrospective study at a tertiary referral centre for head and neck cancers. All consecutive patients who had total laryngectomy over an eight-year period were included.
Results
A total of 140 patients were included. Rates of transient and long-term hypoparathyroidism were 14.3% and 10.1%, respectively. The following factors were significantly associated with transient post-surgical hypocalcaemia or hypoparathyroidism: total thyroidectomy (relative risk, RR, 4.33; 95% confidence interval, CI, 1.86–10.10), oesophagectomy (RR 6.05; 95% CI 2.92–12.53) and female sex (RR 3.23; 95% CI 1.45–7.19). In addition, total thyroidectomy (RR 5.89; 95% CI 1.94–17.86), central neck dissection (RR 3.97; 95% CI 1.42–11.10), oesophagectomy (RR 9.38; 95% CI 4.13–21.3), pharyngectomy (RR 7.14; 95% CI 2.08–24.39) and female sex (RR 5.52; 95% CI 1.95–15.63) were risk factors for long-term hypoparathyroidism. There was variability in the use of preventative measures, monitoring and management of hypocalcaemia and hypoparathyroidism following total laryngectomy.
Conclusions
Transient hypocalcaemia and long-term hypoparathyroidism occur in a significant proportion of patients after laryngectomy. A standard protocol is required to improve care.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021, All rights reserved by the Royal College of Surgeons of England. |
Keywords: | Hypocalcaemia; Hypoparathyroidism; Laryngectomy; Thyroidectomy; Humans; Female; Hypocalcemia; Laryngectomy; Retrospective Studies; Hypoparathyroidism; Risk Factors; Thyroidectomy; Postoperative Complications |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 02 Aug 2024 16:19 |
Last Modified: | 02 Aug 2024 16:19 |
Status: | Published |
Publisher: | Royal College of Surgeons of England |
Refereed: | Yes |
Identification Number: | 10.1308/rcsann.2021.0276 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215365 |