Pashneh-Tala, S., Field, J., Fornesa, B. et al. (5 more authors) (2023) Versatile, elastomeric and degradable polyHIPEs of poly(glycerol sebacate)-methacrylate and their application in vascular graft tissue-engineering. Materials Today Advances, 20. 100432. ISSN 2590-0498
Abstract
Polymer scaffolds are an important enabling technology in tissue engineering. A wide range of manufacturing techniques have been developed to produce these scaffolds, including porogen leaching, phase separation, gas foaming, electrospinning and 3D printing. However, all of these techniques have limitations. Delivering suitable scaffold porosity, small feature sizes and macroscopic geometry remain challenging.
Here, we present the development of a highly versatile scaffold fabrication method utilising emulsion templating to produce polymerised high internal phase emulsions (polyHIPEs) of the polymer poly(glycerol sebacate) methacrylate (PGS-M). PGS-M is biocompatible, degradable and highly elastic, with tunable mechanical properties. PGS-M was formulated into an emulsion using solvents and surfactants and then photocured into polyHIPE structures. The porosity, degradation behaviour, mechanical properties and biocompatibility of the PGS-M polyHIPEs was investigated.
The versatility of the PGS-M polyHIPEs was demonstrated with the production of various complex tubular scaffold shapes, using injection moulding. These shapes were designed for applications in vascular graft tissue engineering and included straight tubes, bends, branches, functioning valves, and a representative aortic arch. The PGS-M polyHIPE scaffolds supported vascular smooth muscle cells (SMCs) in 3D cell culture in a bioreactor.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | PolyHIPE; Poly(glycerol sebacate); Porous polymers; Emulsion templating; Vascular graft; Tissue engineering |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/L012669/1 Engineering and Physical Sciences Research Council EP/M506618/1 Engineering and Physical Sciences Research Council 2262871 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Aug 2024 15:14 |
Last Modified: | 08 Aug 2024 15:14 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.mtadv.2023.100432 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215327 |