Fairclough, S., Chumas, P., Goodden, J. et al. (2 more authors) (2024) Motor seizures confer overall survival benefit in who grade 2 glioma. Epilepsia, 65 (6). pp. 1679-1686. ISSN 0013-9580
Abstract
Objective: The prevalence of epilepsy in World Health Organization (WHO) grade 2 glioma is high, with seizures being the presenting symptom in 60%–90%. We explore the epidemiology of seizures in this patient population in a regional neurosurgical center. Methods: Electronic health records of patients with histologically-proven WHO grade 2 glioma (n = 228) were reviewed between 1997 and 2021, with data collected including patient demographics, epilepsy prevalence, and seizure semiology. The influence of seizure type on overall survival was calculated using a Cox proportional hazards model. Results: Overall, 197 of 228 patients (86.4%) were diagnosed with epilepsy—either at presentation or during the course of their disease. Male patients were more likely than female patients to be diagnosed with epilepsy (91.1% vs 77.1%, p =.003) and, in those with epilepsy, more likely to experience at least one focal to bilateral tonic–clonic seizure (69.4% vs 54.1%, p =.05). Patients with left-sided tumors were twice as likely to have experienced a focal to bilateral tonic–clonic seizure (p =.02, odds ratio [OR] =.47). Predominantly experiencing seizures with motor activity appeared to confer better overall survival, with a 65% decrease in the risk of death 10 years post diagnosis (hazard ratio [HR] =.35, p =.02). This is despite accounting for previously described prognostic markers including tumor histology/genetics, time from diagnosis to surgery, and the extent of tumor resection. Significance: Motor seizure activity is a frequent feature in WHO grade 2 glioma and appears to confer a survival benefit regardless of histology or surgical factors. Seizures due to dominant hemisphere tumors may be more likely to propagate and cause bilateral tonic–clonic activity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | 32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; 3211 Oncology and Carcinogenesis; Patient Safety; Brain Cancer; Epilepsy; Rare Diseases; Neurosciences; Clinical Research; Brain Disorders; Neurodegenerative; Cancer; Neurological; Humans; Male; Female; Middle Aged; Glioma; Brain Neoplasms; Adult; Seizures; Aged; Young Adult; World Health Organization; Retrospective Studies; Neoplasm Grading; Adolescent |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Gastroenterology and Surgery |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Jul 2024 10:34 |
Last Modified: | 25 Jul 2024 10:34 |
Published Version: | http://dx.doi.org/10.1111/epi.17956 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/epi.17956 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215221 |