Large scale genome reconstructions illuminate Wolbachia evolution

Abstract

Wolbachia is an iconic example of a successful intracellular bacterium. Despite its importance as a manipulator of invertebrate biology, its evolutionary dynamics have been poorly studied from a genomic viewpoint. To expand the number of Wolbachia genomes, we screen over 30,000 publicly available shotgun DNA sequencing samples from 500 hosts. By assembling over 1000 Wolbachia genomes, we provide a substantial increase in host representation. Our phylogenies based on both core-genome and gene content provide a robust reference for future studies, support new strains in model organisms, and reveal recent horizontal transfers amongst distantly related hosts. We find various instances of gene function gains and losses in different super-groups and in cytoplasmic incompatibility inducing strains. Our Wolbachia-host co-phylogenies indicate that horizontal transmission is widespread at the host intraspecific level and that there is no support for a general Wolbachia-mitochondrial synchronous divergence.

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Item Type:	Article
Authors/Creators:	Scholz, M. Albanese, D. Tuohy, K. https://orcid.org/0000-0001-6882-7192 Donati, C. Segata, N. Rota-Stabelli, O.
Copyright, Publisher and Additional Information:	© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Keywords:	Biological Sciences; Bioinformatics and Computational Biology; Evolutionary Biology; Genetics; Human Genome; Genetics; Infectious Diseases; Generic health relevance; Evolution, Molecular; Gene Transfer, Horizontal; Genome, Bacterial; Host Specificity; Phylogeny; Wolbachia
Dates:	Published: 16 October 2020 Published (online): 16 October 2020 Accepted: 25 September 2020
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	25 Jul 2024 15:36
Last Modified:	25 Jul 2024 15:36
Published Version:	https://www.nature.com/articles/s41467-020-19016-0
Status:	Published
Publisher:	Springer
Identification Number:	10.1038/s41467-020-19016-0
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:215176

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Large scale genome reconstructions illuminate Wolbachia evolution

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