Gao, G., Zhou, J., Jin, Y. et al. (8 more authors) (2021) Nanoparticles derived from porcine bone soup attenuate oxidative stress-induced intestinal barrier injury in Caco-2 cell monolayer model. Journal of Functional Foods, 83. 104573. ISSN 1756-4646
Abstract
Safety concerns arose on the interaction between nanoparticles in food and intestinal tract. Food components could spontaneously assemble into a large number of nanoparticles during food processing. These nanoparticles may possess physiological effects differed from those of constituent components, are worth paying attention to, but are barely investigated yet, especially on their interaction with intestinal tract. Porcine bone soup is rich in nanoparticles, which can directly interact with oral macrophages disclosed by our previous study. In this study, the effects of bone soup nanoparticles on intestinal barrier function were subsequently evaluated on Caco-2 cell monolayers. The results revealed the nanoparticles did not develop but restore intestinal barrier dysfunction compared with engineered nanoparticles, indicated by barrier integrity, sodium fluorescein permeability, tight junctions and adherent junctions related proteins. These results showed the potential of bone soup nanoparticles on improving intestinal disorders, which resonated with traditional knowledge on the efficacies of bone soup.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Zhejiang Gongshang University. Published by Elsevier Ltd. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY-NC-ND 4.0). |
Keywords: | Bone soup, Nanoparticles, Oxidative stress, Intestinal barrier injury, Caco-2 cell monolayer, AAPH |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Jul 2024 09:50 |
Last Modified: | 25 Jul 2024 09:50 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jff.2021.104573 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215161 |