Pogranyi, Balazs, Mielke, Tamara, Diaz-Rodriguez, Alba et al. (3 more authors) (2024) Preparative Scale Achmatowicz and aza-Achmatowicz Rearrangements Catalyzed by Agrocybe aegerita Unspecific Peroxygenase. Organic and Biomolecular Chemistry. ISSN 1477-0539
Abstract
The unspecific peroxygenase (UPO) from Agrocybe aegerita (rAaeUPO-PaDa-I-H) is an effective and practical biocatalyst for the oxidative expansion of furfuryl alcohols/amines on a preparative scale, using the Achmatowicz and aza-Achmatowicz reaction. The high activity and stability of the enzyme, which can be produced on large scale as an air-stable lyophilised powder, renders it a versatile and scalable biocatalyst for the preparation of synthetically valuable 6-hydroxypyranones and dihydropiperidinones. In several cases, the biotransformation out-performed the analogous chemo-catalysed process, and operates under milder and greener reaction conditions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2024 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Jul 2024 07:00 |
Last Modified: | 16 Oct 2024 20:02 |
Published Version: | https://doi.org/10.1039/d4ob00939h |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1039/d4ob00939h |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:215107 |
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Description: Preparative scale Achmatowicz and aza-Achmatowicz rearrangements catalyzed by Agrocybe aegerita unspecific peroxygenase
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