Lognathan, S., Barimah, E.K., Sharma, G. et al. (7 more authors) (2024) Applications of Near-IR CW and Ultrafast Pulsed Lasers and Photo-active Biominerals in Reconstructive and Restorative Surgery of Hard Tissues. In: 2024 24th International Conference on Transparent Optical Networks (ICTON). 2024 24th International Conference on Transparent Optical Networks (ICTON), 14-18 Jul 2024, Bari, Italy. IEEE ISBN 979-8-3503-7733-0
Abstract
The emergence of ultrashort pulsed near-IR lasers has opened novel opportunities not only for investigating the physics of interaction of such lasers with photo-active biomaterials for reconstructive and restorative bone and dental tissue engineering, but also for analysing the light-matter interaction in the CW laser regime for reconstructive surgical applications. The clinically-relevant examples discussed are for enamel restoration, osteoporotic bone-mass augmentation, and reconstructing damaged bone after trauma. Here, we explain the process of energy absorption in both the CW and ultrashort-pulsed regimes using the heat transfer process which impacts on the mineralisation of tissue. The aspect of thermal management by controlling the repetition rates of ultrashort pulses in near-IR lasers is also explained using sub-ablation and ablation models which are particularly relevant for dental tissue surgical reconstruction. On the other hand, for bone applications both the CW and ultrashort pulsed laser become highly relevant, depending on the type of clinical case for reconstructive surgery. The presentation will also explain the cell/human stem-cell biological characterisations of the laser-treated biomineral scaffolds in vitro for testing the toxicity, cell viability, and proliferation analyses. We will conclude by explaining the need for regulatory process, safety procedures needed prior to animal and first-in-human studies.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
Keywords: | Ultrashort pulsed lasers, bone and dental tissues, restorative and reconstructive surgery, heat transfer, tissue ablation, biominerals |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Funding Information: | Funder Grant number EU - European Union 752297 MRC (Medical Research Council) Exception P.O. 4050781788 Innovate UK fka Technology Strategy Board (TSB) TS/S002022/1 EPSRC (Engineering and Physical Sciences Research Council) EP/G032483/1 EPSRC (Engineering and Physical Sciences Research Council) n/a EPSRC (Engineering and Physical Sciences Research Council) EP/N00941X/1 EPSRC (Engineering and Physical Sciences Research Council) EP/K020234/1 EU - European Union 874896 EU - European Union 953128 |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Jul 2024 09:24 |
Last Modified: | 16 Sep 2024 12:52 |
Published Version: | https://ieeexplore.ieee.org/document/10647756 |
Status: | Published |
Publisher: | IEEE |
Identification Number: | 10.1109/ICTON62926.2024.10647756 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:214987 |