Larvin, H., Baptiste, P.J., Gao, C. orcid.org/0000-0003-1163-2751 et al. (5 more authors) (2024) All‐cause and cause‐specific mortality in US adults with periodontal diseases: A prospective cohort study. Journal Of Clinical Periodontology. ISSN 0303-6979
Abstract
Aim
This prospective cohort study investigated the association between periodontal diseases (PDs) and all-cause and cause-specific mortality.
Materials and Methods
We utilized adult participants recruited from six National Health and Nutrition Examination Survey cycles (1999–2014) and linked mortality data from the National Death Index up to December 2019. Baseline clinical periodontal examinations were performed by trained and calibrated examiners. All-cause and cause-specific mortality was modelled through multivariable Cox proportional hazards and Fine–Gray models to account for competing risks. All models were adjusted for demographic and lifestyle variables, clinical measurements and comorbidities.
Results
Overall, 15,030 participants were included, with a median length of follow-up of 9 years. Risk of all-cause mortality was 22% greater in people with PD than the control group (adjusted hazard ratio [HR]: 1.22, 95% confidence interval [CI]: 1.12–1.31). Risks of mortality by cardiovascular diseases (CVD), respiratory disease and diabetes were highest in participants with severe PD (CVD—sub-distribution HR [SHR]: 1.38, 95% CI: 1.16–1.64; respiratory—SHR: 1.62, 95% CI: 1.07–2.45; diabetes—SHR: 1.68, 95% CI: 1.12–2.53).
Conclusions
Severe PD is associated with all-cause and cause-specific mortality among US adults after multivariable adjustment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Big Data, cohort study, mortality, oral health, periodontal diseases |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Applied Health and Clinical Translation (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Jul 2024 12:43 |
Last Modified: | 17 Jul 2024 12:43 |
Published Version: | https://onlinelibrary.wiley.com/doi/10.1111/jcpe.1... |
Status: | Published online |
Publisher: | Wiley |
Identification Number: | 10.1111/jcpe.14002 |
Related URLs: | |
Sustainable Development Goals: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:214876 |