Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models

Au, W.H. orcid.org/0009-0006-1068-9560, Miller-Fleming, L. orcid.org/0000-0002-3593-6461, Sanchez-Martinez, A. orcid.org/0000-0002-2728-6251 et al. (9 more authors) (2024) Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Life Science Alliance, 7 (9). e202402853. ISSN 2575-1077

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Item Type: Article
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© 2024 Au et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Keywords: Amyotrophic Lateral Sclerosis; Oxidative Stress; NF-E2-Related Factor 2; C9orf72 Protein; Mitochondria; Animals; Disease Models, Animal; Kelch-Like ECH-Associated Protein 1; Humans; Signal Transduction; Frontotemporal Dementia; Phenotype; Drosophila Proteins; Reactive Oxygen Species; Mitophagy; Dimethyl Fumarate; Male
Dates:
  • Published: September 2024
  • Published (online): 21 June 2024
  • Accepted: 4 June 2024
  • Submitted: 30 May 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Funding Information:
Funder
Grant number
PARKINSONS UK
F-1301
Depositing User: Symplectic Sheffield
Date Deposited: 09 Jul 2024 07:51
Last Modified: 09 Jul 2024 07:51
Status: Published
Publisher: Life Science Alliance, LLC
Refereed: Yes
Identification Number: 10.26508/lsa.202402853
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