Farmer, M.A.H. orcid.org/0009-0008-9645-6921, Musa, O.M. and Armes, S.P. orcid.org/0000-0002-8289-6351 (2024) Combining crystallization-driven self-assembly with reverse sequence polymerization-induced self-assembly enables the efficient synthesis of hydrolytically degradable anisotropic block copolymer nano-objects directly in concentrated aqueous media. Journal of the American Chemical Society, 146 (24). pp. 16926-16934. ISSN 0002-7863
Abstract
Herein we combine the well-known processing advantages conferred by polymerization-induced self-assembly (PISA) with crystallization-driven self-assembly (CDSA) to achieve the efficient synthesis of hydrolytically degradable, highly anisotropic block copolymer nano-objects directly in aqueous solution at 30% w/w solids. This new strategy involves a so-called reverse sequence PISA protocol that employs poly(l-lactide) (PLLA) as the crystallizable core-forming block and poly(N,N′-dimethylacrylamide) (PDMAC) as the water-soluble non-ionic coronal block. Such syntheses result in PDMAC-rich anisotropic nanoparticles. Depending on the target diblock copolymer composition, either rod-like nanoparticles or diamond-like platelets can be obtained. Furthermore, N-Acryloylmorpholine is briefly evaluated as an alternative hydrophilic vinyl monomer to DMAC. Given that the PLLA block can undergo either hydrolytic or enzymatic degradation, such nanoparticles are expected to offer potential applications in various fields, including next-generation sustainable Pickering emulsifiers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Copolymers; Nanoparticles; Precursors; RAFT polymerization; Targeting |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/R003009/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 Jul 2024 15:26 |
Last Modified: | 03 Jul 2024 15:26 |
Published Version: | http://dx.doi.org/10.1021/jacs.4c06299 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Refereed: | Yes |
Identification Number: | 10.1021/jacs.4c06299 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:214281 |