Miller, A. orcid.org/0000-0002-8549-5158, Allen, R.J. orcid.org/0000-0002-1887-3016, Juma, A.A. et al. (2 more authors) (2023) Does repetitive transcranial magnetic stimulation improve cognitive function in age‐related neurodegenerative diseases? A systematic review and meta‐analysis. International Journal of Geriatric Psychiatry, 38 (8). e5974. ISSN 0885-6230
Abstract
Objective: High-frequency, repetitive transcranial magnetic stimulation (rTMS) targeted over the dorsolateral prefrontal cortex (DLPFC) is widely used in research to promote neuroplasticity and cognitive enhancement. RTMS is a promising intervention to tackle cognitive decline in people with age-related neurodegenerative diseases. However, there is currently no systematic evidence examining the effects of DLPFC-targeted, high-frequency rTMS on cognitive function in this population. The aim of this systematic review was to evaluate the efficacy and moderators of this treatment intervention.
Methods: A comprehensive literature search of five electronic databases was performed to identify articles published before October, 2022. Following PRISMA guidelines, the identified articles were screened, data was extracted, and the methodological quality was assessed using the Cochrane tool, Risk of Bias 2. Meta-analyses were performed using R Studio (v.4.1.2).
Results: Sixteen studies involving 474 participants met the inclusion criteria, of which 8 studies measured global cognitive function. The results from the random-effects meta-analysis showed rTMS significantly improved global cognitive function relative to control groups shown by a large, significant effect size (g = 1.39, 95% CI, 0.34–2.43; p = 0.017). No significant effects were found between subgroups or for individual cognitive domains.
Conclusions: High-frequency rTMS, targeted over the DLPFC, appears to improve global cognitive function in people with age-related neurodegenerative diseases. However, these results should be interpreted with caution due to the small number of studies included, and high between-study heterogeneity.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2023 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
Keywords: | ageing; Alzheimer's disease; dementia; dorsolateral prefrontal cortex; MCI; TMS |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 219420/Z/19/Z ESRC (Economic and Social Research Council) 221328 Wellcome Trust Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Jul 2024 10:49 |
Last Modified: | 12 Jul 2024 10:49 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/gps.5974 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:214247 |