Yildizbakan, L., Iqbal, N. orcid.org/0000-0002-2801-707X, Giannoudis, P.V. orcid.org/0000-0002-5205-7696 et al. (1 more author) (2024) Synthesis of Chitosan and Ferric-Ion (Fe³⁺)-Doped Brushite Mineral Cancellous Bone Scaffolds. Biomimetics, 9 (6). 308. ISSN 2313-7673
Abstract
Biodegradable scaffolds are needed to repair bone defects. To promote the resorption of scaffolds, a large surface area is required to encourage neo-osteogenesis. Herein, we describe the synthesis and freeze-drying methodologies of ferric-ion (Fe³⁺) doped Dicalcium Phosphate Dihydrate mineral (DCPD), also known as brushite, which has been known to favour the in situ condition for osteogenesis. In this investigation, the role of chitosan during the synthesis of DCPD was explored to enhance the antimicrobial, scaffold pore distribution, and mechanical properties post freeze-drying. During the synthesis of DCPD, the calcium nitrate solution was hydrolysed with a predetermined stoichiometric concentration of ammonium phosphate. During the hydrolysis reaction, 10 (mol)% iron (Fe³⁺) nitrate (Fe(NO₃)₃) was incorporated, and the DCPD minerals were precipitated (Fe3+-DCPD). Chitosan stir-mixed with Fe³⁺-DCPD minerals was freeze-dried to create scaffolds. The structural, microstructural, and mechanical properties of freeze-dried materials were characterized.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Fe³⁺-doped brushite (dicalcium phosphate dihydrate); chitosan; mechanical properties; scaffold; bone tissue engineering |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Orthopaedics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Jul 2024 14:42 |
Last Modified: | 09 Jul 2024 15:01 |
Published Version: | https://www.mdpi.com/2313-7673/9/6/308 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/biomimetics9060308 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:214154 |