Zabihi, M.M., Eghbaliferiz, S., Khorashadizadeh, M. et al. (2 more authors) (Cover date: January 2024) Green synthesis of non-toxic silver nanoparticles using Salvia tebesana Bunge extract: Optimization, cytotoxicity, and antibacterial activities. Results in Chemistry, 7. 101510. ISSN 2211-7156
Abstract
The remarkable antibacterial activity and potential biomedical applications of silver nanoparticles (AgNPs) synthesized through eco-friendly approaches have garnered significant attention in recent years. This research aimed to introduce a green synthesis method for AgNPs using Salvia tebesana (S. tebesana) Bunge extract and to investigate their properties, antibacterial activities, and cytotoxicity effects. The fabricated AgNPs were analyzed with various analyses, including UV–Vis, DLS, XRD, FT-IR, and TEM analysis. The broth microdilution assay was applied to measure the Minimum Inhibitory Concentrations (MIC) of chemical AgNPs, biosynthesized AgNPs, and S. tebesana Bunge leaves extract alone against selected standard bacteria strains. The biosynthesized AgNPs displayed a surface plasmon resonance peak at approximately 415 nm, and the AgNPs synthesized using S. tebesana Bunge extract had a spherical configuration with an average size in the range of 10–15 nm. Biosynthesized nanoparticles showed a noteworthy antibacterial activity compared to chemical nanoparticles, particularly against P. aeruginosa, with the highest antibacterial activity reported at a MIC value of 39.06 μg/mL. AgNPs synthesized using S. tebesana Bunge extract demonstrated a significant decrease in fibroblast cell viability, but only when the concentration reached 2 mg/mL. The findings demonstrate that S. tebesana Bunge leaves extract enhances the antibacterial properties of AgNPs, and also represents an appropriate and biocompatible option for the synthesis of these nanoparticles. Our research highlights the potential of employing bio-safe and eco-friendly AgNPs synthesized in the presence of S. tebesana Bunge extract, which possess remarkable antibacterial properties, for various biomedical applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/bync/4.0/). |
Keywords: | Silver nanoparticles; S. tebesana Bunge; Green synthesis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jul 2024 15:40 |
Last Modified: | 11 Jul 2024 15:40 |
Published Version: | http://dx.doi.org/10.1016/j.rechem.2024.101510 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.rechem.2024.101510 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:214085 |