Arp, D.T., Appelt, A.L. orcid.org/0000-0003-2792-9218, Brøndum, R.F. et al. (3 more authors) (2024) Individual lymph node position variation for rectal cancer patients treated with long course chemoradiotherapy. Physics and Imaging in Radiation Oncology, 31. 100599. ISSN 2405-6316
Abstract
Background and purpose
Delivery of high precision radiotherapy lymph node boosts requires detailed information on the interfraction positional variation of individual lymph nodes. In this study we characterized interfraction positional shifts of suspected malignant lymph nodes for rectal cancer patients receiving long course radiotherapy. Furthermore, we investigated parameters which could affect the magnitude of the position variation.
Materials and Methods
Fourteen patients from a prospective clinical imaging study with a total of 61 suspected malignant lymph nodes in the mesorectum, presacral, and lateral regions, were included. The primary gross tumor volume (GTVp) and all suspected malignant lymph nodes were delineated on six magnetic resonance imaging scans per patient. Positional variation was calculated as systematic and random errors, based on shifts of center-of-mass, and estimated relative to either bony structures or the GTVp using a hierarchical linear mixed model.
Results
Depending on location and direction, systematic and random variations (relative to bony structures) were within 0.6–2.8 mm and 0.6–2.9 mm, respectively. Systematic and random variations increased when evaluating position relative to GTVp (median increase of 0.6 mm and 0.5 mm, respectively). Correlations with scan time-point and relative bladder volume were found in some directions.
Conclusions
Using linear mixed modeling, we estimated systematic and random positional variation for suspected malignant lymph nodes in rectal cancer patients treated with long course radiotherapy. Statistically significant correlations of the magnitude of the lymph node shifts were found related to scan time-point and relative bladder volume.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Published by Elsevier. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY-NC-ND 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Rectal cancer; Radiotherapy; Non-surgical; Systematic and random errors; Positional variation; Lymph nodes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Oncology |
Funding Information: | Funder Grant number Yorkshire Cancer Research Account Ref: 2UOLEEDS Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Jul 2024 12:33 |
Last Modified: | 03 Jul 2024 12:33 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.phro.2024.100599 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:213859 |