Clark, A.K. orcid.org/0000-0003-4359-3697, Wright, G., Mason, J. et al. (4 more authors) (2023) Single- and dual-source-strength focal boost planning in low-dose-rate prostate brachytherapy: feasibility study. Journal of Radiotherapy in Practice, 22. e106. ISSN 1460-3969
Abstract
Introduction: This study investigates the dose escalation to dominant intra-prostatic lesions (DILs) that is achievable using single-source-strength (SSS) and dual-source-strength (DSS) low-dose-rate (LDR) prostate brachytherapy and a sector-based plan approach.
Methods: Twenty patients were retrospectively analysed. Image registration and planning were undertaken using VariSeed v9·0. SSS and DSS boost plans were produced and compared to clinical plans. Dosimetric robustness to seed displacement for SSS and DSS plans was compared to clinical plans using Monte Carlo simulations.
Results: Fourteen out of 20 patients had DIL identifiable on magnetic resonance imaging. Median increase in sector D90 of 27% (p < 0·0001) and sector V150 of 31% (p < 0·0001) was achieved with SSS planning without exceeding local rectum and urethra dose constraints. DSS plans achieved dose distributions not statistically significantly different from the SSS plans with a median of eight fewer seeds and two fewer needles. SSS and DSS plan sensitivity to random seed displacement was similar to the clinical plans.
Conclusions: Treatment planning using VariSeed to produce SSS and DSS focal boost plans is feasible for LDR prostate brachytherapy to achieve a median escalation in sector D90 of 27% without exceeding local urethral and rectal constraints. SSS and DSS plan dosimetric robustness was similar to clinical plan dosimetric robustness.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s), 2023. This article has been published in a revised form in https://doi.org/10.1017/S1460396923000225. This version is free to view and download for private research and study only. Not for re-distribution or re-use. |
Keywords: | Dual source strength; Focal boost; Prostate brachytherapy |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Oncology |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Jun 2024 09:23 |
Last Modified: | 04 Jun 2024 10:39 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1017/s1460396923000225 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:213097 |