Craske, Matthew W, Wilson, Jason S and Fogg, Paul C M orcid.org/0000-0001-5324-4293 (2024) Gene transfer agents:structural and functional properties of domesticated viruses. Trends in microbiology. pp. 1200-1211. ISSN 0966-842X
Abstract
Horizontal exchange of DNA between bacteria and archaea is prevalent and has major potential implications for genome evolution, plasticity, and population fitness. Several transfer mechanisms have been identified, including gene transfer agents (GTAs). GTAs are intricately regulated domesticated viruses that package host DNA into virus-like capsids and transfer this DNA throughout the bacterial community. Several important advances have recently been made in our understanding of these unusual particles. In this review, we highlight some of these findings, primarily for the model GTA produced by Rhodobacter capsulatus but also for newly identified GTA producers. We provide key insights into these important genetic elements, including the differences between GTAs from their ancestral bacteriophages, their regulation and control, and their elusive evolutionary function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Author(s) |
Keywords: | Gene Transfer Agent,Horizontal gene transfer,Evolution,BACTERIA,viruses,DNA Repair,gene regulation |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Funding Information: | Funder Grant number BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL) BB/V016288/1 |
Depositing User: | Pure (York) |
Date Deposited: | 05 Jun 2024 08:20 |
Last Modified: | 07 Jan 2025 12:10 |
Published Version: | https://doi.org/10.1016/j.tim.2024.05.002 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.tim.2024.05.002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:213070 |
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Filename: PIIS0966842X24001331.pdf
Description: Gene transfer agents: structural and functional properties of domesticated viruses
Licence: CC-BY 2.5