Zinc N,N-bis(2-picolyl)amine chelates show substitution-dependent cleavage of phosphodiesters in models as well as of PNAzyme-RNA bulges

Svenningsen, S.W., Luige, O. orcid.org/0000-0002-1448-5630, Abdulkarim, Z. et al. (2 more authors) (2024) Zinc N,N-bis(2-picolyl)amine chelates show substitution-dependent cleavage of phosphodiesters in models as well as of PNAzyme-RNA bulges. Molecules, 29 (9). 2123. ISSN 1420-3049

Abstract

Metadata

Item Type: Article
Authors/Creators:
Copyright, Publisher and Additional Information:

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Keywords: PNAzyme; RNA bulge; RNA substrate; metal chelate; phosphodiester cleavage; Zinc; Peptide Nucleic Acids; Chelating Agents; RNA; Catalysis; Amines; Kinetics; Organophosphates
Dates:
  • Published: 3 May 2024
  • Published (online): 3 May 2024
  • Accepted: 24 April 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 28 May 2024 11:03
Last Modified: 28 May 2024 11:03
Published Version: http://dx.doi.org/10.3390/molecules29092123
Status: Published
Publisher: MDPI AG
Refereed: Yes
Identification Number: 10.3390/molecules29092123
Related URLs:
Open Archives Initiative ID (OAI ID):

Export

Statistics