Eljounaidi, Kaouthar orcid.org/0000-0003-4675-226X, Radzikowska, Barbara A, Whitehead, Caragh B et al. (10 more authors) (2024) Variation of terpene alkaloids in Daphniphyllum macropodum across plants and tissues. The New phytologist. pp. 299-313. ISSN 1469-8137
Abstract
Daphniphyllum macropodum produces alkaloids that are structurally complex with polycyclic, stereochemically rich carbon skeletons. Understanding how these compounds are formed by the plant may enable exploration of their biological function and bioactivities. We employed multiple metabolomics techniques, including a workflow to annotate compounds in the absence of standards, to compare alkaloid content across plants and tissues. Different alkaloid structural types were found to have distinct distributions between genotypes, between tissues and within tissues. Alkaloid structural types also showed different isotope labelling enrichments that matched their biosynthetic relationships. The work suggests that mevalonate derived 30-carbon alkaloids are formed in the phloem region before their conversion to 22-carbon alkaloids which accumulate in the epidermis. This sets the stage for further investigation into the biosynthetic pathway.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Publisher Copyright: © 2024 The Authors. New Phytologist © 2024 New Phytologist Foundation. |
Keywords: | alkaloids,biosynthesis,Daphniphyllum,metabolomics,specialised metabolism |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Biology (York) > Centre for Novel Agricultural Products (CNAP) (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 May 2024 08:00 |
Last Modified: | 28 Feb 2025 00:08 |
Published Version: | https://doi.org/10.1111/nph.19814 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1111/nph.19814 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:212767 |
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Description: New Phytologist - 2024 - Eljounaidi - Variation of terpene alkaloids in Daphniphyllum macropodum across plants and tissues
Licence: CC-BY 2.5