Voisin, A., Plaschka, M., Perrin-Niquet, M. et al. (14 more authors) (2024) The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer. Frontiers in Immunology, 15. 1379777. ISSN 1664-3224
Abstract
CD8⁺ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8⁺ T cell-autonomous roles of the different NF-κB subunits, are still unresolved. Here, we investigated the function of the ubiquitously expressed transcription factor RelA in CD8⁺ T-cell biology using a novel mouse model and gene-edited human cells. We found that CD8⁺ T cell-specific ablation of RelA markedly altered the transcriptome of ex vivo stimulated cells, but maintained the proliferative capacity of both mouse and human cells. In contrast, in vivo experiments showed that RelA deficiency did not affect the CD8⁺ T-cell response to acute viral infection or transplanted tumors. Our data suggest that in CD8⁺ T cells, RelA is dispensable for their protective activity in pathological contexts.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 Voisin, Plaschka, Perrin-Niquet, Twardowski, Boutemine, Eluard, Lalle, Ste´ phan, Bouherrou, Tonon, Pommier, Ferrari, Klein, Wencker, Baud, Cassier and Grinberg-Bleyer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: | CD8⁺T cells; NF-KappaB; cancer; immunotherapy; LCMV |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Haematology and Immunology |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 May 2024 10:27 |
Last Modified: | 10 May 2024 10:27 |
Published Version: | https://www.frontiersin.org/journals/immunology/ar... |
Status: | Published |
Publisher: | Frontiers Media |
Identification Number: | 10.3389/fimmu.2024.1379777 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:212375 |