Farr, N.T.H. orcid.org/0000-0001-6761-3600, Workman, V.L., Chapple, C.R. et al. (2 more authors) (2024) Strengthening preclinical testing to increase safety in surgical mesh. Nature Reviews Urology, 21. pp. 515-516. ISSN 1759-4812
Abstract
Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged. We report poor responses of polypropylene mesh to repeated mechanical distension and macrophage interrogation. These results from preclinical in vitro testing show the potential of this approach for testing and improving materials before their introduction into the clinic.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 Springer Nature Limited |
Keywords: | Preclinical research; Urology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 02 May 2024 10:54 |
Last Modified: | 20 Nov 2024 10:36 |
Status: | Published |
Publisher: | Springer Science and Business Media LLC |
Refereed: | Yes |
Identification Number: | 10.1038/s41585-024-00889-5 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:212209 |