Miller, Alex Henrique, Thompson, Sean, Blagova, Lena et al. (3 more authors) (2024) Redox-reversible siderophore-based catalyst anchoring within cross-linked artificial metalloenzyme aggregates enables enantioselectivity switching. Chemical communications. pp. 5490-5493. ISSN 1364-548X
Abstract
The immobilisation of artificial metalloenzymes (ArMs) holds promise for the implementation of new biocatalytic reactions. We present the synthesis of cross-linked artificial metalloenzyme aggregates (CLArMAs) with excellent recyclability, as alternative to carrier-based immobilisation strategies. Furthermore, iron-siderophore supramolecular anchoring facilitates redox-triggered cofactor release, enabling CLArMAs to be recharged with alternative cofactors for diverse selectivity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2024 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number UNSPECIFIED EP/T007338/1 BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL) BB/W011131/1 |
Depositing User: | Pure (York) |
Date Deposited: | 29 Apr 2024 15:20 |
Last Modified: | 18 Dec 2024 00:25 |
Published Version: | https://doi.org/10.1039/D4CC01158A |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/D4CC01158A |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:211955 |