Aram, E., Sadeghi‐Abandansari, H. orcid.org/0000-0002-3548-168X, Radmanesh, F. et al. (5 more authors) (2024) Shell-sheddable and charge switchable magnetic nanoparticle as pH-sensitive nanocarrier for targeted drug delivery applications. Polymers for Advanced Technologies, 35 (4). e6366. ISSN 1042-7147
Abstract
A pH-sensitive shell-sheddable magnetic nanocarrier was prepared based on Fe3O4@SiO2 nanoparticles coated with polyethyleneimine (PEI) and polyethyleneglycol (PEG). The PEI was coated on Fe3O4@SiO2 nanoparticles through an electrostatic attraction and the PEG chains were connected to the PEI via pH-sensitive benzoic-imine bonds. The synthesized products and final nanocarrier were characterized with FT-IR, 1H NMR, dynamic light scattering (DLS), zeta-potential, TEM, and vibrating-sample magnetometer (VSM). The PEI, as a middle layer, was used to load the curcumin (an anticancer drug) via van der Waals interactions and the shedding of PEG as a hydrophilic corona at the tumor pH (acidic) could induce the release of the drug. The curcumin loading content was found to be ~15% and curcumin-loaded magnetic nanoparticles (C-LMNs) showed more triggered release at the tumor pH (5.6) than physiological pH (7.4). In comparison to pure magnetic nanoparticles (MNs), the C-LMNs showed more cytotoxicity to human prostate cancer cell (PC-3) and also resulted in an increased rate of late apoptotic/necrotic PC-3 cells, assessed by flow cytometry analysis. In conclusion, the C-LMN as pH- and magnetic responsive nanocarrier showed good potential for targeted curcumin delivery in therapy of prostate cancer.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | curcumin; magnetic nanoparticle; prostate cancer; shell-sheddable; targeted delivery |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Apr 2024 15:05 |
Last Modified: | 23 Apr 2024 15:05 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/pat.6366 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:211699 |