Pope, Ian, Clark, Lucy V, Clark, Allan et al. (16 more authors) (2024) Cessation of Smoking Trial in the Emergency Department (COSTED):a multicentre randomised controlled trial. Emergency Medicine Journal. ISSN 1472-0213
Abstract
Background Supporting people to quit smoking is one of the most powerful interventions to improve health. The Emergency Department (ED) represents a potentially valuable opportunity to deliver a smoking cessation intervention if it is sufficiently resourced. The objective of this trial was to determine whether an opportunistic ED-based smoking cessation intervention can help people to quit smoking. Methods In this multicentre, parallel-group, randomised controlled superiority trial conducted between January and August 2022, adults who smoked daily and attended one of six UK EDs were randomised to intervention (brief advice, e-cigarette starter kit and referral to stop smoking services) or control (written information on stop smoking services). The primary outcome was biochemically validated abstinence at 6 months. Results An intention-to-treat analysis included 972 of 1443 people screened for inclusion (484 in the intervention group, 488 in the control group). Of 975 participants randomised, 3 were subsequently excluded, 17 withdrew and 287 were lost to follow-up. The 6-month biochemically-verified abstinence rate was 7.2% in the intervention group and 4.1% in the control group (relative risk 1.76; 95% CI 1.03 to 3.01; p=0.038). Self-reported 7-day abstinence at 6 months was 23.3% in the intervention group and 12.9% in the control group (relative risk 1.80; 95% CI 1.36 to 2.38; p<0.001). No serious adverse events related to taking part in the trial were reported. Conclusions An opportunistic smoking cessation intervention comprising brief advice, an e-cigarette starter kit and referral to stop smoking services is effective for sustained smoking abstinence with few reported adverse events. Trial registration number NCT04854616.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Author(s) (or their employer(s)) 2024 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 12 Apr 2024 14:20 |
Last Modified: | 16 Oct 2024 19:52 |
Published Version: | https://doi.org/10.1136/emermed-2023-213824 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1136/emermed-2023-213824 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:211466 |
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Filename: emermed-2023-213824.full.pdf
Description: Cessation of Smoking Trial in the Emergency Department (COSTED): a multicentre randomised controlled trial
Licence: CC-BY 2.5