Karademir, Y., Mackie, A., Tuohy, K. orcid.org/0000-0001-6882-7192 et al. (1 more author) (2024) Effects of Ferulic Acid on Cognitive Function: A Systematic Review. Molecular Nutrition & Food Research, 68 (13). e2300526. ISSN 1613-4125
Abstract
Scope Plant (poly) phenolic compounds have been reported to decrease the risk of developing dementia and have been associated with maintenance of cognitive performance in normal ageing. Ferulic acid (FA) is a phenolic acid, present in a wide variety of foods including cereals, fruits, vegetables, and coffee. The aim of this systematic review is to examine the effect of FA on cognitive function in humans and animals.
Methods and results The search terms “Ferulic acid AND cognit*” and “Ferulic acid OR feruloyl OR ferula AND (memory OR attention OR learning OR recognition)” are used in Web of Science, Scopus, PubMED, OVID (Medline/PsycInfo), and CINAHL through October 2023. No human studies are identified that matched the inclusion criteria. Twenty-six animal studies are identified. A small number (n = 5) of these studies examined FA in healthy animals whilst the remainder examined animal models of dementia. Alzheimer's disease (n = 11) is the most prevalent model.
Conclusion Overall, results from studies employing disease models suggest that FA ameliorates induced cognitive decline in a time and dose-dependent manner. Similarly, studies in healthy animals show a beneficial effect of FA. However, further studies are required to determine the effects of FA on human cognitive function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | cognition; dementia; ferulic acid; in vivo; phenolics |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Apr 2024 10:42 |
Last Modified: | 15 Oct 2024 13:09 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mnfr.202300526 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:210644 |