Aderinto, S.O., John, T. orcid.org/0000-0001-6059-5964, Onawole, A. et al. (2 more authors) (2024) Iridium(iii)-based minor groove binding complexes as DNA photocleavage agents. Dalton Transactions, 53 (17). pp. 7282-7291. ISSN 1477-9226
Abstract
Transition metal complexes containing the qtpy ligand (2′:4,4′′:4′,4′′′-quaterpyridyl) are known to be DNA intercalators or minor groove binders. In this study, new tricationic iridium(III) complexes of qtpy are reported. Both [Ir(bpy)2(qtpy)]3+ 1 and [Ir(phen)2(qtpy)]3+ 2 display good water solubility as chloride salts. The complexes possess high-energy excited states, which are quenched in the presence of duplex DNA and even by the mononucleotides guanosine monophosphate and adenosine monophosphate. Further studies reveal that although the complexes bind to quadruplex DNA, they display a preference for duplex structures, which are bound with an order of magnitude higher affinities than their isostructural dicationic RuII-analogues. Detailed molecular dynamics simulations confirm that the complexes are groove binders through the insertion of, predominantly, the qtpy ligand into the minor groove. Photoirradiation of 1 in the presence of plasmid DNA confirms that this class of complexes can function as synthetic photonucleases by cleaving DNA.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2024. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. (http://creativecommons.org/licenses/by-nc/3.0/) |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Mar 2024 09:41 |
Last Modified: | 14 Nov 2024 15:46 |
Status: | Published |
Publisher: | Royal Society of Chemistry (RSC) |
Refereed: | Yes |
Identification Number: | 10.1039/d4dt00171k |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:210478 |