Saha, Promeet, Tran Ngoc, Trung, McGonigal, Paul Ronald James orcid.org/0000-0002-8538-7579 et al. (1 more author) (2024) Geometry-Controlled Reactivity and Dynamics in Organic Molecules. Nature Synthesis. ISSN 2731-0582
Abstract
It is well-established that strain in organic molecules is linked to having nonideal bond lengths, bond angles, and unfavourable non-bonded interactions. The constrained geometries of ring systems are particularly predisposed to creating strain. Recently, there has been increased interest in leveraging this property of rings as a synthetic tool by building strain into substrates to activate a desired bond cleavage step. But one could also envisage alternative uses of strain. In this review, we outline how geometry control can be exploited to ‘switch on’ dynamic processes or stabilize reactive transition states. By designing constrained molecular structures that direct strain on particular bonds or functional groups, transformations that are otherwise energetically uphill can become favoured. This phenomenon can subvert our expectations about the reactivity and properties of organic molecules, giving rise to unusual bonding modes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the University’s Research Publications and Open Access policy. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 15 Mar 2024 09:40 |
Last Modified: | 16 Oct 2024 19:50 |
Published Version: | https://doi.org/10.1038/s44160-024-00526-4 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1038/s44160-024-00526-4 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:210273 |
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Description: Geometry-Controlled Reactivity and Dynamics in Organic Molecules
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