Qiang, Z. orcid.org/0000-0001-8271-8507, Jubber, I., Lloyd, K. et al. (2 more authors) (2023) Gene of the month: GATA3. Journal of Clinical Pathology, 76 (12). pp. 793-797. ISSN 0021-9746
Abstract
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in GATA3 are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic response. It also has clinical relevance in squamous cell carcinomas and soft tissue sarcomas. This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical marker.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Author(s) (or their employer(s)). This is an author-produced version of a paper subsequently published in Journal of Clinical Pathology. Uploaded in accordance with the publisher's self-archiving policy. No commercial re-use. |
Keywords: | breast neoplasms; immunohistochemistry; molecular biology; pathology, molecular; urologic neoplasms; Humans; Female; Breast; Urinary Bladder Neoplasms; Mutation; GATA3 Transcription Factor; Breast Neoplasms; Biomarkers, Tumor |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number YORKSHIRE CANCER RESEARCH S431 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Mar 2024 15:32 |
Last Modified: | 04 Mar 2024 21:45 |
Status: | Published |
Publisher: | BMJ |
Refereed: | Yes |
Identification Number: | 10.1136/jcp-2023-209017 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:209832 |