Zalessky, Illya, Wootton, Jack M, Tam, Jerry K F et al. (11 more authors) (2024) A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions. Journal of the American Chemical Society. ISSN 1520-5126
Abstract
Macrocycles and medium-sized rings are important in many scientific fields and technologies but are hard to make using current methods, especially on a large scale. Outlined herein is a strategy by which functionalized macrocycles and medium-sized rings can be prepared using cyclization/ring expansion (CRE) cascade reactions, without resorting to high dilution conditions. CRE cascade reactions are designed to operate exclusively via kinetically favorable 5-7-membered ring cyclization steps; this means that the problems typically associated with classical end-to-end macrocyclization reactions are avoided. A modular synthetic approach has been developed to facilitate the simple assembly of the requisite linear precursors, which can then be converted into an extremely broad range of functionalized macrocycles and medium-sized rings using one of nine CRE protocols.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 23 Feb 2024 09:50 |
Last Modified: | 11 Mar 2025 00:10 |
Published Version: | https://doi.org/10.1021/jacs.4c00659 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1021/jacs.4c00659 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:209547 |
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Description: A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions
Licence: CC-BY 2.5