Guellil, Meriam, van Dorp, Lucy, Inskip, Sarah A. et al. (18 more authors) (2022) Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia. Science Advances. eabo4435. ISSN 2375-2548
Abstract
Human herpes simplex virus 1 (HSV-1), a life-long infection spread by oral contact, infects a majority of adults globally. Phylogeographic clustering of sampled diversity into European, pan-Eurasian, and African groups has suggested the virus codiverged with human migrations out of Africa, although a much younger origin has also been proposed. We present three full ancient European HSV-1 genomes and one partial genome, dating from the 3rd to 17th century CE, sequenced to up to 9.5× with paired human genomes up to 10.16×. Considering a dataset of modern and ancient genomes, we apply phylogenetic methods to estimate the age of sampled modern Eurasian HSV-1 diversity to 4.68 (3.87 to 5.65) ka. Extrapolation of estimated rates to a global dataset points to the age of extant sampled HSV-1 as 5.29 (4.60 to 6.12) ka, suggesting HSV-1 lineage replacement coinciding with the late Neolithic period and following Bronze Age migrations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Arts and Humanities (York) > Archaeology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 14 Feb 2024 09:20 |
Last Modified: | 01 Apr 2025 23:11 |
Published Version: | https://doi.org/10.1126/sciadv.abo4435 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1126/sciadv.abo4435 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:209184 |
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Filename: sciadv.abo4435.pdf
Description: Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia
Licence: CC-BY 2.5