Tachtatzis, P., Spoletini, G. orcid.org/0000-0002-5462-0083, Clifton, I. orcid.org/0000-0002-9758-9506 et al. (2 more authors) (2024) Changes in liver biochemistry and tacrolimus levels following the introduction of elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis and liver transplant. Journal of Cystic Fibrosis, 23 (1). pp. 99-102. ISSN 1569-1993
Abstract
Introduction Elevated liver function tests (LFTs) are reported in individuals with cystic fibrosis (CF) starting elexacaftor/tezacaftor/ivacaftor (ETI). We report our experience with ETI in CF liver transplant patients.
Method All CF liver transplant patients under the care of the Leeds CF team were commenced on ETI. Liver biopsies were performed when ALT >3 times upper limit of normal with or without bilirubin elevation. Treatment was guided by transplant hepatology and CF teams. Clinical data including lung function, LFTs and tacrolimus levels were collected.
Results Four patients (3 male, 1 female) on tacrolimus were commenced on ETI. Median time post liver transplantation was 6.5 years. Three patients underwent liver biopsy. One biopsy was abnormal with immune-mediated liver injury, which responded to increased immunosuppression. Management of tacrolimus levels proved straightforward.
Conclusion ETI therapy in CF post liver transplant recipients was encouraging. Normal liver biopsy provides re-assurance to continue treatment despite elevated LFTs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Cystic fibrosis; Elexacaftor; Ivacaftor; Liver biopsy; Liver function test; Liver transplant; Tezacaftor |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Molecular Medicine |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Jan 2024 11:03 |
Last Modified: | 20 May 2024 13:02 |
Published Version: | https://www.cysticfibrosisjournal.com/article/S156... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jcf.2023.04.023 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:208022 |