Salvaris, R. orcid.org/0000-0003-1053-5503, Mulligan, S. orcid.org/0000-0003-1928-2098, Puig, A. orcid.org/0000-0002-7730-6310 et al. (2 more authors) (2023) Australian data on the utilisation and duration on treatment of ibrutinib with a proton pump inhibitor in patients with relapsed or refractory chronic lymphocytic leukaemia. Internal Medicine Journal, 53 (11). pp. 2115-2118. ISSN 1444-0903
Abstract
In Australia, over half of patients with relapsed/refractory chronic lymphocytic leukaemia treated with ibrutinib use concomitant proton pump inhibitors (PPIs). High gastric pH reduces the bioavailability of some Bruton tyrosine kinase inhibitors. There was no difference in duration on ibrutinib with or without concomitant PPI (unadjusted P = 0.61; adjusted hazard ratio: 1.23, 95% confidence interval: 0.75–2.02, P = 0.411). PPI use does not affect ibrutinib treatment persistence.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: | Australia; Bruton tyrosine kinase (BTK) inhibitors; chronic lymphocytic leukaemia; ibrutinib; proton pump inhibitor (PPI); real-world evidence; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Proton Pump Inhibitors; Neoplasm Recurrence, Local; Australia; Protein Kinase Inhibitors |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Jan 2024 11:52 |
Last Modified: | 19 Jan 2024 11:52 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/imj.16267 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:207961 |