Wymeersch, F.J. orcid.org/0000-0001-8999-4555, Wilson, V. orcid.org/0000-0003-4182-5159 and Tsakiridis, A. orcid.org/0000-0002-2184-2990 (2021) Understanding axial progenitor biology in vivo and in vitro. Development, 148 (4). dev180612. ISSN 0950-1991
Abstract
The generation of the components that make up the embryonic body axis, such as the spinal cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction. This process is driven by the coordinated production of various cell types from a pool of posteriorly-located axial progenitors. Here, we review the key features of this process and the biology of axial progenitors, including neuromesodermal progenitors, the common precursors of the spinal cord and trunk musculature. We discuss recent developments in the in vitro production of axial progenitors and their potential implications in disease modelling and regenerative medicine.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Published by The Company of Biologists Ltd. This is an author-produced version of a paper subsequently published in Development. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Axis elongation; Gastrulation; Neuromesodermal progenitors; Pluripotent stem cells; Primitive streak; Tail bud; Animals; Biology; Body Patterning; Ectoderm; Endoderm; Gastrulation; Gene Expression Regulation, Developmental; Germ Layers; Humans; In Vitro Techniques; Mesoderm; Muscle, Skeletal; Stem Cells |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Funding Information: | Funder Grant number BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL BB/P000444/1 Children's Cancer and Leukaemia Group CCLGA 2019 28 MEDICAL RESEARCH COUNCIL MR/V002163/1 EUROPEAN COMMISSION - HORIZON 2020 824070 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 23 Jan 2024 11:59 |
Last Modified: | 23 Jan 2024 11:59 |
Status: | Published |
Publisher: | The Company of Biologists |
Refereed: | Yes |
Identification Number: | 10.1242/dev.180612 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:207900 |