Mass spectrometric analysis of the active site tryptic peptide of recombinant O6-methylguanine-DNA methyltransferase following incubation with human colorectal DNA reveals the presence of an O6-alkylguanine adductome

Abdelhady, R., Senthong, P., Eyers, C.E. et al. (11 more authors) (2023) Mass spectrometric analysis of the active site tryptic peptide of recombinant O6-methylguanine-DNA methyltransferase following incubation with human colorectal DNA reveals the presence of an O6-alkylguanine adductome. Chemical Research in Toxicology, 36 (12). pp. 1921-1929. ISSN 0893-228X

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Item Type: Article
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© 2023 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Humans; Catalytic Domain; Colorectal Neoplasms; Cysteine; DNA; DNA Repair; Mass Spectrometry; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Peptides
Dates:
  • Published: 18 December 2023
  • Published (online): 20 November 2023
  • Accepted: 1 November 2023
  • Submitted: 14 July 2023
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 05 Jan 2024 11:04
Last Modified: 05 Jan 2024 11:04
Status: Published
Publisher: American Chemical Society (ACS)
Refereed: Yes
Identification Number: 10.1021/acs.chemrestox.3c00207
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