Engel, M. orcid.org/0000-0002-0143-1908, Mueller, L. orcid.org/0000-0002-9605-9183, Döring, A. orcid.org/0000-0002-2096-5374 et al. (2 more authors) (2023) Maximizing SNR per unit time in diffusion MRI with multiband T-Hex spirals. Magnetic Resonance in Medicine. ISSN 0740-3194
Abstract
Purpose
The characterization of tissue microstructure using diffusion MRI (dMRI) signals is rapidly evolving, with increasing sophistication of signal representations and microstructure models. However, this progress often requires signals to be acquired with very high b-values (e.g., b > 30 ms/μm2), along many directions, and using multiple b-values, leading to long scan times and extremely low SNR in dMRI images. The purpose of this work is to boost the SNR efficiency of dMRI by combining three particularly efficient spatial encoding techniques and utilizing a high-performance gradient system (Gmax ≤ 300 mT/m) for efficient diffusion encoding.
Methods
Spiral readouts, multiband imaging, and sampling on tilted hexagonal grids (T-Hex) are combined and implemented on a 3T MRI system with ultra-strong gradients. Image reconstruction is performed through an iterative cg-SENSE algorithm incorporating static off-resonance distributions and field dynamics as measured with an NMR field camera. Additionally, T-Hex multiband is combined with a more conventional EPI-readout and compared with state-of-the-art blipped-CAIPIRINHA sampling. The advantage of the proposed approach is furthermore investigated for clinically available gradient performance and diffusion kurtosis imaging.
Results
High fidelity in vivo images with b-values up to 40 ms/μm2 are obtained. The approach provides superior SNR efficiency over other state-of-the-art multiband diffusion readout schemes.
Conclusion
The demonstrated gains hold promise for the widespread dissemination of advanced microstructural scans, especially in clinical populations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | diffusion MRI, magnetic field monitoring, multiband, simultaneous multi-slice, spiral imaging |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Biomedical Imaging Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Jan 2024 11:51 |
Last Modified: | 08 Jan 2024 14:09 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mrm.29953 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:207027 |