Taccola, G. orcid.org/0000-0003-2675-1438, Kissane, R. orcid.org/0000-0001-9385-2584, Culaclii, S. orcid.org/0000-0002-3496-1286 et al. (6 more authors) (2023) Spinal facilitation of descending motor input. [Preprint - Cold Spring Harbor Laboratory]
Abstract
Highly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS, we introduced a corticospinal platform that allows selective cortical stimulation during the multisite acquisition of cord dorsum potentials (CDPs) and the simultaneous supply of DS. Firstly, the epidural interface was validated by the acquisition of the classical multisite distribution of CDPs on the dorsal cord and their input-output profile elicited by pulses delivered to peripheral nerves. Apart from increased EMGs, DS selectively increased excitability of the spinal interneurons that first process corticospinal input, without changing the magnitude of commands descending from the motor cortex, suggesting a novel correlation between muscle recruitment and components of cortically-evoked CDPs. Finally, DS increases excitability of post-synaptic spinal interneurons at the stimulation site and their responsiveness to any residual supraspinal control, thus supporting the use of electrical neuromodulation whenever the motor output is jeopardized by a weak volitional input, due to a partial disconnection from supraspinal structures and/or neuronal brain dysfunctions.
Metadata
Item Type: | Preprint |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license. |
Keywords: | Cord Dorsum Potentials; Epidural neuroprosthesis; Multielectrode arrays; Muscle recruitment; Neuromodulation; Noisy waveforms; Spinal cord; Spinal reflex |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Jan 2024 14:05 |
Last Modified: | 05 Jan 2024 14:05 |
Published Version: | http://dx.doi.org/10.1101/2023.06.30.547229 |
Status: | Published |
Publisher: | Cold Spring Harbor Laboratory |
Identification Number: | 10.1101/2023.06.30.547229 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:206921 |