Espino-Gonzalez, E., Tickle, P.G., Altara, R. et al. (17 more authors) (2024) Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction. JACC: Basic to Translational Science, 9 (2). pp. 223-240. ISSN 2452-302X
Abstract
Heart failure with preserved ejection fraction (HFpEF) is a major clinical problem, with limited treatments. HFpEF is characterized by a distinct, but poorly understood, skeletal muscle pathology, which could offer an alternative therapeutic target. In a rat model, we identified impaired myonuclear accretion as a mechanism for low myofiber growth in HFpEF following resistance exercise. Acute caloric restriction rescued skeletal muscle pathology in HFpEF, whereas cardiac therapies had no effect. Mechanisms regulating myonuclear accretion were dysregulated in patients with HFpEF. Overall, these findings may have widespread implications in HFpEF, indicating combined dietary with exercise interventions as a beneficial approach to overcome skeletal muscle pathology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY License (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | diet; exercise training; HFpEF; mitochondria; skeletal muscle |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Dec 2023 16:03 |
Last Modified: | 22 Mar 2024 09:51 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jacbts.2023.09.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:206601 |