Zhou, Weiyin, Fischer, Anja, Ogwang, Martin D et al. (44 more authors) (2023) Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa. Nature Communications. 8081. ISSN 2041-1723
Abstract
In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin-MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma (P-values = 5.7×10-11 and 3.74×10-2, respectively). Autosomal mosaic chromosomal alterations are detected in 14.0% of Ghanaian men and increase with age. Mosaic chromosomal alterations in Burkitt lymphoma cases include gains on chromosomes 1q and 8, the latter spanning MYC, while mosaic chromosomal alterations in Burkitt lymphoma-free children include copy-neutral loss of heterozygosity on chromosomes 10, 14, and 16. Our results highlight mosaic chromosomal alterations in sub-Saharan African populations as a promising area of research.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023. |
Keywords: | Male,Child,Humans,Burkitt Lymphoma/genetics,Ghana,Chromosome Aberrations,Leukocytes/pathology,Immunoglobulins/genetics,Translocation, Genetic |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 13 Dec 2023 09:10 |
Last Modified: | 16 Oct 2024 19:39 |
Published Version: | https://doi.org/10.1038/s41467-023-43881-0 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1038/s41467-023-43881-0 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:206581 |
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Description: Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
Licence: CC-BY 2.5