Seling, Nico, Atobe, Masakazu, Kasten, Kevin et al. (4 more authors) (2023) α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping. Angewandte Chemie International Edition. e202314423. ISSN 1433-7851
Abstract
A general and straightforward procedure for the lithiation / trapping of cyclic sulfides such as tetrahydrothiophene, tetrahydrothiopyran and a thiomorpholine is described. Trapping with a wide range of electrophiles is demonstrated, leading to more than 50 diverse α-substituted saturated sulfur heterocycles. The methodology provides access to a range of α-substituted cyclic sulfides that are not easily synthesised by the currently available methods.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. |
Keywords: | Organolithium, cyclic sulfides, α-functionalization |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number THE ROYAL SOCIETY INF\R1\191028 EPSRC EP/P011217/1 EPSRC EP/V048139/1 |
Depositing User: | Pure (York) |
Date Deposited: | 27 Nov 2023 15:50 |
Last Modified: | 16 Oct 2024 19:37 |
Published Version: | https://doi.org/10.1002/anie.202314423 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/anie.202314423 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:206001 |
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Description: Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping
Licence: CC-BY 2.5