Chivardi, Carlos, Morgan, Holly, Sculpher, Mark J orcid.org/0000-0003-3746-9913 et al. (9 more authors) (2023) Percutaneous Revascularisation for Ischemic Left Ventricular Dysfunction:Cost-Effectiveness Analysis of the REVIVED-BCIS2 Trial. Circulation. Cardiovascular quality and outcomes. ISSN 1941-7705
Abstract
Background: Percutaneous coronary intervention (PCI) is frequently undertaken in patients with ischemic left ventricular systolic dysfunction (ILVD). The REVIVED-BCIS2 trial concluded that PCI did not reduce the incidence of all-cause death or heart failure (HF) hospitalization, however patients assigned to PCI reported better initial health-related quality of life than those assigned to optimal medical therapy (OMT) alone. The aim of this study was to assess the cost-effectiveness of PCI+OMT compared with OMT alone. Methods: REVIVED-BCIS2 was a prospective, multi-centre UK trial, which randomized patients with severe ILVD to either PCI+OMT or OMT alone. Healthcare resource use (including planned and unplanned revascularizations, medication, device implantation and HF hospitalizations) and health outcomes data (EQ-5D-5L questionnaire) on each patient were collected at baseline and up to 8 years post-randomization. Resource use was costed using publicly available national unit costs. Within trial mean total costs and quality-adjusted life years (QALYs) were estimated from the perspective of the UK health system. Cost-effectiveness was evaluated using estimated mean costs and QALYs in both groups. Regression analysis was used to adjust for clinically relevant predictors. Results: Between 2013 and 2020, 700 patients were recruited (mean age: PCI+OMT=70, OMT=68; male (%): PCI+OMT=87, OMT=88); median follow up was 3.4 years. Over all follow-up, patients undergoing PCI yielded similar health benefits at higher costs compared to OMT alone (PCI+OMT: 4.14 QALYs, £22,352; OMT alone: 4.16 QALYs; £15,569; Difference: -0.015; £6,782). For both groups most health resource consumption occurred in the first 2 years post-randomization. Probabilistic results showed that the probability of PCI being cost-effective was 0. Conclusions: Minimal difference in total QALYs was identified between arms and PCI+OMT was not cost-effective compared to OMT, given its additional cost. A strategy of routine PCI to treat ILVD does not appear to be a justifiable use of healthcare resource in the UK. Clinical Trial Registration: URL: https://clinicaltrials.gov/ Unique Identifier: NCT01920048.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Social Sciences (York) > Centre for Health Economics (York) The University of York > Faculty of Arts and Humanities (York) > Music (York) |
Depositing User: | Pure (York) |
Date Deposited: | 13 Nov 2023 15:00 |
Last Modified: | 28 Feb 2025 00:08 |
Published Version: | https://doi.org/10.1161/CIRCOUTCOMES.123.010533 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1161/CIRCOUTCOMES.123.010533 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:205273 |
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Description: chivardi-et-al-2023-percutaneous-revascularisation-for-ischemic-left-ventricular-dysfunction-cost-effectiveness
Licence: CC-BY 2.5