Does Flavonoid Supplementation Alleviate Non‐Alcoholic Fatty Liver Disease? A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Abstract

Scope

Higher flavonoid intake is associated with reduced risk of non-alcoholic fatty liver disease (NAFLD). However, there is a large discrepancy in the effects of flavonoid supplementation on NAFLD. To fill such knowledge gap, we systematically reviewed randomized clinical trials (RCTs) to critically assess flavonoid supplementation effect on liver function, lipid profile, inflammation, and insulin resistance in adults with NAFLD.

Methods and results

A systematic search was conducted from 4 databases from inception until May 2023. Twelve RCTs were included in the final analysis demonstrating beneficial effects of flavonoids on ALT (SMD = −3.59, p = 0.034), AST (SMD = −4.47, p = 0.001), GGT (SMD = −8.70, p = 0.000), CK-18M30 (SMD = −0.35, p = 0.042), TG (SMD = −0.37, p = 0.001), LDL-C (SMD = −0.38, p = 0.039), TC (MD = −0.25 mmol/l, p = 0.017), steatosis score (MD = −18.97, p = 0.30), TNF-α (MD = −0.88, p = 0.000), and NF-κB (MD = −1.62, p = 0.001).

Conclusion

This meta-analysis suggests that flavonoid alleviates NAFLD through exerting favourable effects on liver function, lipid profile, and inflammation, indicating flavonoid supplementation presents a promising drug regimen for the management of NAFLD and its associated complications.

Metadata

Item Type:	Article
Authors/Creators:	Li, L. https://orcid.org/0000-0002-2299-6588 Ji, K. Du, F. Jin, N. Boesch, C. https://orcid.org/0000-0001-6705-5709 Farag, M.A. Li, H. https://orcid.org/0000-0001-7459-9202 Liu, X. Xiao, J. https://orcid.org/0000-0003-3311-770X
Copyright, Publisher and Additional Information:	© 2023 Wiley-VCH GmbH. This is the peer reviewed version of the following article: Li, L., Ji, K., Du, F., Jin, N., Boesch, C., Farag, M. A., Li, H., Liu, X., Xiao, J., Does Flavonoid Supplementation Alleviate Non-Alcoholic Fatty Liver Disease? A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Mol. Nutr. Food Res. 2023, 2300480. https://doi.org/10.1002/mnfr.202300480, which has been published in final form at https://doi.org/10.1002/mnfr.202300480. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Dates:	Published: 30 November 2023 Published (online): 25 October 2023
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	07 Nov 2023 16:45
Last Modified:	25 Oct 2024 00:13
Status:	Published
Publisher:	Wiley
Identification Number:	10.1002/mnfr.202300480
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:204984

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Does Flavonoid Supplementation Alleviate Non‐Alcoholic Fatty Liver Disease? A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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