Delgado Spicuzza, J.M. orcid.org/0000-0002-3183-0707, Proctor, D.N., Thijssen, D.H.J. et al. (1 more author) (2023) Menopausal stage differences in endothelial resistance to ischemia‐reperfusion injury. Physiological Reports, 11 (18). e15768. ISSN 2051-817X
Abstract
Background
In postmenopausal women, reduced ovarian function precedes endothelial dysfunction and attenuated endothelial resistance to ischemia-reperfusion (IR) injury. We hypothesized that IR injury would lower endothelial function, with premenopausal women demonstrating the greatest protection from injury, followed by early, then late postmenopausal women.
Methods
Flow-mediated dilation (FMD) was assessed at baseline and following IR injury in premenopausal (n = 11), early (n = 11; 4 ± 1.6 years since menopause), and late (n = 11; 15 ± 5.5 years since menopause) postmenopausal women.
Results
There were significant group differences in baseline FMD (p = 0.007); post hoc analysis revealed a similar resting FMD between premenopausal (7.8% ± 2.1%) and early postmenopausal (7.1% ± 2.7%), but significantly lower FMD in late postmenopausal women (4.5% ± 2.3%). Results showed an overall decline in FMD after IR injury (p < 0.001), and a significant condition*time interaction (p = 0.048), with early postmenopausal women demonstrating the most significant decline in FMD following IR.
Conclusion
Our findings indicate that endothelial resistance to IR injury is attenuated in healthy early postmenopausal women.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Humans; Reperfusion Injury; Health Status; Menopause; Rest; Female |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Oct 2023 09:59 |
Last Modified: | 30 Oct 2023 09:59 |
Published Version: | https://physoc.onlinelibrary.wiley.com/doi/10.1481... |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.14814/phy2.15768 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:204660 |