Spicer, Chris orcid.org/0000-0001-8787-578X, Grey, William George orcid.org/0000-0001-8209-5645, Barber, Lydia et al. (4 more authors) (2023) Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones. Biomacromolecules. ISSN 1525-7797
Abstract
Thiol-reactive Michael acceptors are commonly used for the formation of chemically cross-linked hydrogels. In this paper, we address the drawbacks of many Michael acceptors by introducing pyridazinediones as new cross-linking agents. Through the use of pyridazinediones and their mono- or dibrominated analogues, we show that the mechanical strength, swelling ratio, and rate of gelation can all be controlled in a pH-sensitive manner. Moreover, we demonstrate that the degradation of pyridazinedione-gels can be induced by the addition of thiols, thus providing a route to responsive or dynamic gels, and that monobromo-pyridazinedione gels are able to support the proliferation of human cells. We anticipate that our results will provide a valuable and complementary addition to the existing toolkit of cross-linking agents, allowing researchers to tune and rationally design the properties of biomedical hydrogels.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Physics (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 225257/Z/22/Z LEVERHULME TRUST RPG-2022-174 |
Depositing User: | Pure (York) |
Date Deposited: | 05 Oct 2023 14:10 |
Last Modified: | 15 Feb 2025 00:11 |
Published Version: | https://doi.org/10.1021/acs.biomac.3c00290 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.biomac.3c00290 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:203999 |