Ould Setti, Mounir, Voutilainen, Ari, Tajik, Behnam orcid.org/0000-0002-8453-3909 et al. (2 more authors) (2021) Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men:34 years of follow-up. Scandinavian Journal of Gastroenterology. pp. 1096-1102. ISSN 1502-7708
Abstract
BACKGROUND AND OBJECTIVES: Fatty liver disease (FLD) and hypertension are separately associated with cardiovascular (CV) mortality. The two conditions are related in multiple ways. This work aimed to study the joint effect and interaction of FLD and hypertension in respect to overall and CV mortality. METHODS: The population-based cohort, Kuopio Ischaemic Disease Risk Factor Study, followed 1569 middle-aged non-diabetic Finnish men for 34 years. Considering adjustment for age, body mass index, smoking and alcohol consumption, separate and combined effects of FLD and hypertension and their interaction at the multiplicative and additive scales regarding all-cause and CV death were assessed using Cox proportional hazards models. RESULTS: FLD and hypertension coexisted in 8.54% of the men (n = 134). FLD and hypertension associated, independently and combined, with an increased hazard of all-cause and CV deaths. Non-CV mortality associated with FLD, but not with hypertension. We found a negative interaction between FLD and hypertension regarding the hazard of all-cause (relative excess risk due to interaction (RERI), -0.97; 95% confidence interval (CI), -1.65 to -0.28) and CV mortality (RERI, -1.74; 95% CI, -2.98 to -0.5). The interaction was also found on a multiplicative scale. CONCLUSIONS: We found evidence of a negative interaction between FLD and hypertension in respect to CV mortality. We thus recommend adjusting for FLD or hypertension when studying the effect of the other condition on mortality or CV diseases in middle-aged men.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Author(s) |
Keywords: | Body Mass Index,Cardiovascular Diseases/etiology,Fatty Liver,Follow-Up Studies,Humans,Hypertension/complications,Male,Middle Aged |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 04 Oct 2023 07:40 |
Last Modified: | 08 Feb 2025 00:51 |
Published Version: | https://doi.org/10.1080/00365521.2021.1951836 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1080/00365521.2021.1951836 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:203923 |
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Description: Negative interaction of fatty liver and hypertension on cardiovascular mortality in non-diabetic men 34 years of follow-up
Licence: CC-BY-NC-ND 2.5