Tajik, Behnam orcid.org/0000-0002-8453-3909, Voutilainen, Ari, Kauhanen, Jussi et al. (4 more authors) (2022) Lipid profile, lipid ratios, apolipoproteins, and risk of cardiometabolic multimorbidity in men:The Kuopio Ischaemic Heart Disease Risk Factor Study. Lipids. pp. 141-149. ISSN 1558-9307
Abstract
The blood level of lipids, apolipoproteins, and lipid ratios are important predictors of some chronic diseases. However, their association with cardiometabolic multimorbidity (CMM) is less known. We evaluated a wide range of lipid profiles and lipid ratios, including low-density lipoprotein-cholesterol (LDL-C), very-low-density lipoprotein-cholesterol (VLDL-C), high-density lipoprotein-cholesterol (HDL-C), and apoA1 and B, as well triglyceride and total cholesterol with risk of incident CMM. In 1728 men aged 52.5 ± 5.2 years from the Kuopio Ischaemic Heart Disease were included in this study. We defined CMM as coexisting of two or more of stroke, type 2 diabetes mellitus (T2D), coronary heart disease (CHD). A Cox proportional hazard regression method was applied to evaluate the risk of CMM against the exposures. During the mean follow-up of 22.4 years, 335 men suffered from CMM conditions. Higher serum triglyceride and VLDL concentrations were associated with a higher risk of coexisting T2D-CHD (HRs 1.99 (95% CI, 1.12-3.53) and HRs 1.79 (95% CI, 1.04-3.11), respectively. Whereas higher HDL was associated with lower incident [HRs 0.49 (95% CI, 0.40-1.00)]. The HRs for coexisting T2D-CHD was 2.02 (95% CI, 1.01-3.07) for total cholesterol/HDL-C, 1.85 (95% CI, 1.04-3.29) for triglyceride/HDL-C, 1.69 (95% CI, 1.01-2.31) for Non-HDL-C/HDL-C, and 1.89 (95% CI, 1.03-2.46) for apoB/apoA1. In contrast, serum LDL-C/apoB ratios were inversely associated with the risk of coexisting T2D-CHD [HRs 0.50 (95% CI, 0.28-0.90)]. No associations were observed between our exposures and other CMM conditions. In conclusion, elevated triglyceride, VLDL-C, total cholesterol/HDL-C, TG/HDL-C, apoB/apoA1 as well as lower LDL-C/apoB were independently associated with the higher risk of T2D-CHD coexistence.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors |
Keywords: | Apolipoproteins,Apolipoproteins B,Cholesterol, HDL,Cholesterol, LDL,Coronary Disease/epidemiology,Diabetes Mellitus, Type 2/epidemiology,Female,Heart Disease Risk Factors,Humans,Male,Multimorbidity,Risk Factors,Triglycerides |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 04 Oct 2023 07:40 |
Last Modified: | 16 Oct 2024 19:29 |
Published Version: | https://doi.org/10.1002/lipd.12337 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/lipd.12337 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:203920 |
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Description: Lipids - 2022 - Tajik - Lipid profile lipid ratios apolipoproteins and risk of cardiometabolic multimorbidity in men
Licence: CC-BY 2.5