Wright, M.H. orcid.org/0000-0003-2731-4707 (Cover date: September 2023) Chemical biology tools for protein labelling: insights into cell-cell communication. Biochemical journal, 480 (18). pp. 1445-1457. ISSN 0264-6021
Abstract
Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell-cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out of protein activity or interactions in downstream signalling pathways, or discover protein-protein interactions across cell-cell interfaces.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
Keywords: | biochemical techniques and resources, cell–cell communication, chemical biology, proteomics, signalling |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Oct 2023 14:29 |
Last Modified: | 04 Oct 2023 14:29 |
Published Version: | https://portlandpress.com/biochemj/article/480/18/... |
Status: | Published |
Publisher: | Portland Press |
Identification Number: | 10.1042/bcj20220309 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:203875 |
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