Sutton, J.A.F., Cooke, M., Tinajero-Trejo, M. et al. (6 more authors) (2023) The roles of GpsB and DivIVA in Staphylococcus aureus growth and division. Frontiers in Microbiology, 14. 1241249. ISSN 1664-302X
Abstract
The spheroid bacterium Staphylococcus aureus is often used as a model of morphogenesis due to its apparently simple cell cycle. S. aureus has many cell division proteins that are conserved across bacteria alluding to common functions. However, despite intensive study, we still do not know the roles of many of these components. Here, we have examined the functions of the paralogues DivIVA and GpsB in the S. aureus cell cycle. Cells lacking gpsB display a more spherical phenotype than the wild-type cells, which is associated with a decrease in peripheral cell wall peptidoglycan synthesis. This correlates with increased localization of penicillin-binding proteins at the developing septum, notably PBPs 2 and 3. Our results highlight the role of GpsB as an apparent regulator of cell morphogenesis in S. aureus.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Sutton, Cooke, Tinajero-Trejo, Wacnik, Salamaga, Portman-Ross, Lund, Hobbs and Foster. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: | cell division; divisome; Staphylococcus aureus; GpsB; DivIVA; cell morphology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Sep 2023 11:51 |
Last Modified: | 20 Sep 2023 11:51 |
Status: | Published |
Publisher: | Frontiers Media SA |
Refereed: | Yes |
Identification Number: | 10.3389/fmicb.2023.1241249 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:203506 |