Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition

Martin, H.L., Turner, A.L., Higgins, J. et al. (14 more authors) (2023) Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition. Cell Reports, 42 (10). 113184. ISSN 2211-1247

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Martin, H.L.
  • Turner, A.L.
  • Higgins, J.
  • Tang, A.A.
  • Tiede, C.
  • Taylor, T.
  • Siripanthong, S.
  • Adams, T.L.
  • Manfield, I.
  • Bell, S.M.
  • Morrison, E.E.
  • Bond, J.
  • Trinh, C.
  • Hurst, C.D.
  • Knowles, M.A.
  • Bayliss, R.
  • Tomlinson, D. ORCID logo https://orcid.org/0000-0003-4134-7484
Copyright, Publisher and Additional Information:

© 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Keywords: Affimer, high-content screening, urothelial cancer, PAK5, kinase, structural biology, signaling
Dates:
  • Published: 31 October 2023
  • Published (online): 2 October 2023
  • Accepted: 13 September 2023
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds)
Funding Information:
Funder
Grant number
Wellcome Trust
102174/B/13/Z
Depositing User: Symplectic Publications
Date Deposited: 19 Sep 2023 09:25
Last Modified: 06 Oct 2023 14:29
Published Version: https://www.cell.com/cell-reports/fulltext/S2211-1...
Status: Published
Publisher: Elsevier
Identification Number: 10.1016/j.celrep.2023.113184
Open Archives Initiative ID (OAI ID):

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