Atanas, A.A., Kim, J., Wang, Z. et al. (14 more authors) (Cover date: September 14, 2023) Brain-wide representations of behavior spanning multiple timescales and states in C. elegans. Cell, 186 (19). P4134-4151.E31. ISSN 0092-8674
Abstract
Changes in an animal's behavior and internal state are accompanied by widespread changes in activity across its brain. However, how neurons across the brain encode behavior and how this is impacted by state is poorly understood. We recorded brain-wide activity and the diverse motor programs of freely moving C. elegans and built probabilistic models that explain how each neuron encodes quantitative behavioral features. By determining the identities of the recorded neurons, we created an atlas of how the defined neuron classes in the C. elegans connectome encode behavior. Many neuron classes have conjunctive representations of multiple behaviors. Moreover, although many neurons encode current motor actions, others integrate recent actions. Changes in behavioral state are accompanied by widespread changes in how neurons encode behavior, and we identify these flexible nodes in the connectome. Our results provide a global map of how the cell types across an animal's brain encode its behavior.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). |
Keywords: | C. elegans; behavior; brain-wide activity; cell atlas; internal states; neural circuits |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/J004057/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Sep 2023 10:53 |
Last Modified: | 28 Sep 2023 15:44 |
Published Version: | https://www.cell.com/cell/fulltext/S0092-8674(23)0... |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cell.2023.07.035 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:203287 |
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