Lintern, N., Smith, A.M., Jayne, D.G. orcid.org/0000-0002-8725-3283 et al. (1 more author) (2023) Photodynamic Stromal Depletion in Pancreatic Ductal Adenocarcinoma. Cancers, 15 (16). 4135. ISSN 2072-6694
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid malignancies, with a five-year survival of less than 10%. The resistance of the disease and the associated lack of therapeutic response is attributed primarily to its dense, fibrotic stroma, which acts as a barrier to drug perfusion and permits tumour survival and invasion. As clinical trials of chemotherapy (CT), radiotherapy (RT), and targeted agents have not been successful, improving the survival rate in unresectable PDAC remains an urgent clinical need. Photodynamic stromal depletion (PSD) is a recent approach that uses visible or near-infrared light to destroy the desmoplastic tissue. Preclinical evidence suggests this can resensitise tumour cells to subsequent therapies whilst averting the tumorigenic effects of tumour–stromal cell interactions. So far, the pre-clinical studies have suggested that PDT can successfully mediate the destruction of various stromal elements without increasing the aggressiveness of the tumour. However, the complexity of this interplay, including the combined tumour promoting and suppressing effects, poses unknowns for the clinical application of photodynamic stromal depletion in PDAC.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | cancer therapeutics; extracellular matrix; fibrosis; pancreatic ductal adenocarcinoma; photodynamic therapy; stroma; tumour microenvironment |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Gastroenterology and Surgery |
Funding Information: | Funder Grant number Bowel Cancer UK 18SC0001 |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Sep 2023 10:53 |
Last Modified: | 06 Sep 2023 10:53 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/cancers15164135 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:203076 |